Free L-carnitine in human semen: its variability in different andrologic pathologies

Fertil Steril. 1984 Aug;42(2):263-7. doi: 10.1016/s0015-0282(16)48024-6.


Free L-carnitine was assayed in semen from patients with various andrologic diseases by an enzymatic-spectrophotometric method. Extremely low concentrations were found in semen from patients with agenesis of the vas deferens (31.8 +/- 18.8 nm/ml). Semen from men with vasectomies contains a higher concentration of free carnitine (105.0 +/- 8.1 nm/ml). When comparing these data with those of ten fertile control subjects (817.0 +/- 200 nm/ml), we assume that seminal free L-carnitine mainly originates from the epididymis. Semen from patients with azoospermia caused by testicular failure also contains a low carnitine concentration. In hypogonadotropic eunuchoids the gonadotropin treatment increased the low basal concentration. A correlation between semen carnitine content and sperm motility and number was also tested in 124 infertile patients. The results show a positive correlation between free L-carnitine and sperm count (r = 0.617; P less than 0.01), between free L-carnitine and sperm motility (r = 0.614; P less than 0.01), and between free L-carnitine and the number of motile spermatozoa per milliliter (r = 0.646; P less than 0.01).

MeSH terms

  • Adult
  • Carnitine / analysis*
  • Chorionic Gonadotropin / therapeutic use
  • Humans
  • Hypogonadism / drug therapy
  • Hypogonadism / physiopathology
  • Klinefelter Syndrome / physiopathology
  • Male
  • Menotropins / therapeutic use
  • Semen / analysis*
  • Sperm Count
  • Sperm Motility
  • Vas Deferens / abnormalities
  • Vasectomy


  • Chorionic Gonadotropin
  • Menotropins
  • Carnitine