Effect of intrabiliary administration of Triton X-100 on biliary excretory function in the rat

Biochem Pharmacol. 1984 Jul 15;33(14):2309-13. doi: 10.1016/0006-2952(84)90671-3.


Intrabiliary administration of Triton X-100 is of interest in producing effects on biliary tree permeability and canalicular biliary excretory function. Treatment with 0.4% Triton (40 microliter) was shown to increase the biliary excretion of intraportally administered [3H]sucrose. It also decreased recovery of [3H]sucrose given into the biliary tree. Thus, we concluded that Triton treatment increased biliary tree permeability. Using a different set of marker compounds, canalicular transport of bromphenol blue, [14C]morphine glucuronide and [3H]ouabain was found to be decreased. The fact that [3H] taurocholate excretion into bile was not affected whereas that of [3H]ouabain was lends support to the concept that taurocholate and ouabain are not transported by a common pathway.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bile / drug effects*
  • Bile / metabolism
  • Bile Ducts
  • Bromphenol Blue / metabolism
  • Detergents / pharmacology*
  • Injections
  • Injections, Intravenous
  • Male
  • Mannitol / metabolism
  • Morphine / metabolism
  • Octoxynol
  • Ouabain / metabolism
  • Polyethylene Glycols / pharmacology*
  • Portal Vein
  • Rats
  • Rats, Inbred Strains
  • Sucrose / metabolism
  • Surface-Active Agents / pharmacology*
  • Taurocholic Acid / metabolism


  • Detergents
  • Surface-Active Agents
  • Bromphenol Blue
  • Mannitol
  • Polyethylene Glycols
  • Sucrose
  • Ouabain
  • Taurocholic Acid
  • Morphine
  • Octoxynol