Hemangioblastoma of the central nervous system: nature of the stromal cells as studied by the immunoperoxidase technique

Hum Pathol. 1984 Sep;15(9):866-9. doi: 10.1016/s0046-8177(84)80148-3.


Ten hemangioblastomas of the central nervous system were examined by an immunoperoxidase technique for glial fibrillary acidic protein (GFAP), S-100 protein, and Factor VIII-related antigen to determine the origin of the stromal cells. In seven cases scattered stromal cells were positive for GFAP, and eight cases showed variable numbers of S-100 protein-positive cells. These positive cells were present throughout the tumors. S-100 protein-positive stromal cells corresponded to GFAP-positive cells, but the former were more numerous than the latter. Staining for Factor VIII-related antigen was negative in stromal cells, except in endothelial cells lining capillaries. It was suggested that stromal cells of capillary hemangioblastomas are composed by heterogeneous cell populations.

MeSH terms

  • Adult
  • Antigens / analysis
  • Antigens, Neoplasm / analysis
  • Cerebellar Neoplasms / pathology
  • Cerebral Ventricle Neoplasms / pathology
  • Factor VIII / analysis
  • Factor VIII / immunology
  • Female
  • Glial Fibrillary Acidic Protein
  • Hemangiosarcoma / immunology
  • Hemangiosarcoma / metabolism
  • Hemangiosarcoma / pathology*
  • Histocytochemistry
  • Humans
  • Immunoenzyme Techniques
  • Intermediate Filament Proteins / analysis
  • Male
  • Middle Aged
  • Neoplasm Proteins / analysis
  • Nervous System Neoplasms / immunology
  • Nervous System Neoplasms / metabolism
  • Nervous System Neoplasms / pathology*
  • S100 Proteins / analysis
  • von Willebrand Factor


  • Antigens
  • Antigens, Neoplasm
  • Glial Fibrillary Acidic Protein
  • Intermediate Filament Proteins
  • Neoplasm Proteins
  • S100 Proteins
  • von Willebrand Factor
  • Factor VIII