Effect of gold salts, D-penicillamine and benoxaprofen on type II collagen-induced arthritis in rats

Agents Actions. 1984 Jun;14(5-6):707-14. doi: 10.1007/BF01978912.


We investigated the therapeutic effect of two gold salts, gold sodium thiomalate (GST, i.m.) and auranofin (p.o.), D-penicillamine (p.o.) and benoxaprofen (p.o.) in rat collagen-induced arthritis using type II collagen from fetal bovine articular cartilage. GST, but not auranofin, reduced hind paw edema and bone pathology. However, auranofin reduced serum copper and zymosan-induced prostaglandin production from peritoneal macrophages. In contrast, GST increased both serum copper and macrophage prostaglandin production by zymosan. Benoxaprofen reduced both hind paw edema and pathology, whereas D-penicillamine was without effect. None of these treatments influenced the circulating level of antibody to type II collagen.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Antibodies / analysis
  • Arthritis / chemically induced*
  • Arthritis / immunology
  • Auranofin
  • Aurothioglucose / analogs & derivatives
  • Aurothioglucose / pharmacology
  • Collagen* / immunology
  • Copper / blood
  • Diarrhea / chemically induced
  • Gold Sodium Thiomalate / pharmacology
  • Male
  • Penicillamine / pharmacology
  • Propionates / pharmacology
  • Rats
  • Rats, Inbred Strains


  • Anti-Inflammatory Agents
  • Antibodies
  • Propionates
  • Gold Sodium Thiomalate
  • benoxaprofen
  • Aurothioglucose
  • Auranofin
  • Copper
  • Collagen
  • Penicillamine