Information for the dorsal--ventral pattern of the Drosophila embryo is stored as maternal mRNA

Nature. 1984 Sep 20-26;311(5983):223-7. doi: 10.1038/311223a0.


Maternal-effect mutations in 10 loci in Drosophila produce totally 'dorsalized' embryos. Injection of RNA isolated from wild-type embryos into mutants at six loci partially restores dorsal-ventral polarity. For the mutant snake, injection of poly(A)+ RNA restores a complete dorsal-ventral pattern.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drosophila melanogaster / embryology*
  • Drosophila melanogaster / genetics
  • Morphogenesis
  • Phenotype
  • RNA, Messenger / genetics*


  • RNA, Messenger