Behavioral control of intractable idiopathic seizures: I. Self-regulation of end-tidal carbon dioxide

Psychosom Med. Jul-Aug 1984;46(4):315-31. doi: 10.1097/00006842-198407000-00002.


Eleven women and seven men with moderate to severe chronic hyperventilation and idiopathic seizures refractory to therapeutic serum levels of anticonvulsant medication were given diaphragmatic respiration training with percent end-tidal CO2 biofeedback. The training had a rapid correcting effect on their respiration, making it comparable to that of 18 asymptomatic control subjects. Ten of the seizure-group subjects were in the study at least 7 months and following treatment, 8 showed EEG power spectrum "normalization", restoration of cardio-respiratory synchrony (RSA), and their seizure frequency and severity were significantly reduced.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Biofeedback, Psychology*
  • Carbon Dioxide / physiology*
  • Child
  • Electrocardiography
  • Electroencephalography
  • Epilepsy / therapy*
  • Epilepsy, Tonic-Clonic / therapy
  • Female
  • Humans
  • Hyperventilation / therapy
  • Male
  • Respiration*


  • Carbon Dioxide