Lithium and tryptophan augmentation in clomipramine-resistant obsessive-compulsive disorder

Am J Psychiatry. 1984 Oct;141(10):1283-5. doi: 10.1176/ajp.141.10.1283.

Abstract

Obsessive-compulsive patients with symptoms resistant to clomipramine were treated by lithium or L-tryptophan augmentation. The improvement noted supports the hypothesis that increasing serotonergic neurotransmission ameliorates obsessive symptoms.

Publication types

  • Case Reports
  • Clinical Trial

MeSH terms

  • Adult
  • Clinical Trials as Topic
  • Clomipramine / therapeutic use*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Humans
  • Lithium / therapeutic use*
  • Lithium Carbonate
  • Male
  • Obsessive-Compulsive Disorder / drug therapy*
  • Obsessive-Compulsive Disorder / psychology
  • Psychiatric Status Rating Scales
  • Tryptophan / therapeutic use*

Substances

  • Lithium Carbonate
  • Tryptophan
  • Lithium
  • Clomipramine