Neurotoxic effects of endogenous materials: quinolinic acid, L-pyroglutamic acid, and thyroid releasing hormone (TRH)

Exp Neurol. 1984 Nov;86(2):410-3. doi: 10.1016/0014-4886(84)90197-3.

Abstract

The previously reported, dose-related, and selective neurotoxic action of 100 to 200 nmol quinolinic acid on intrastriatal injection was confirmed. A slight neurotoxicity was obtained with 250 nmol thyroid releasing hormone but not with a similar dose of L-pyroglutamic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Choline O-Acetyltransferase / metabolism
  • Corpus Striatum / drug effects*
  • Corpus Striatum / enzymology
  • Glutamate Decarboxylase / metabolism
  • Kainic Acid / toxicity
  • Pyridines / toxicity*
  • Pyrrolidinones / toxicity*
  • Pyrrolidonecarboxylic Acid / toxicity*
  • Quinolinic Acids / toxicity*
  • Rats
  • Rats, Inbred Strains
  • Thyrotropin-Releasing Hormone / toxicity*

Substances

  • Pyridines
  • Pyrrolidinones
  • Quinolinic Acids
  • Thyrotropin-Releasing Hormone
  • Choline O-Acetyltransferase
  • Glutamate Decarboxylase
  • Kainic Acid
  • Pyrrolidonecarboxylic Acid