Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multi-infarct dementia

J Neural Transm. 1984;60(2):133-41. doi: 10.1007/BF01245030.


Synapsin I (Protein I), a neuron-specific phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), from patients with multi-infarct dementia (MID), and from age-matched controls. Samples were obtained at autopsy. Lower levels of Synapsin I were observed in the hippocampus of patients with AD/SDAT but not with MID. There were no significant differences in Synapsin I levels between patients and controls in any of the other four brain regions examined.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain Chemistry*
  • Caudate Nucleus / analysis
  • Dementia / metabolism*
  • Gyrus Cinguli / analysis
  • Hippocampus / analysis
  • Humans
  • Mesencephalon / analysis
  • Nerve Tissue Proteins / analysis*
  • Putamen / analysis
  • Radioimmunoassay
  • Synapsins


  • Nerve Tissue Proteins
  • Synapsins