Familial growth retardation with isolated thyroid-stimulating hormone deficiency

Clin Pediatr (Phila). 1984 Dec;23(12):675-8. doi: 10.1177/000992288402301202.


Three brothers with isolated thyroid-stimulating hormone (TSH) deficiency were observed at ages 17, 15, and 10 years. They suffered from severely retarded growth, with a marked retardation in bone maturation. Their serum T4, T3, and TSH levels were low. Serum thyrotropin-releasing hormone (TRH) concentration was normal. No increases in TSH levels were elicited during the TRH test. The other pituitary hormones, adrenocorticotropic hormone, growth hormone, follicle-stimulating hormone, luteinizing hormone, and prolactin hormone, responded normally to stimulation. Thyroxin treatment triggered a growth acceleration. Genetic investigation revealed several instances of small stature on the father's side.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Child
  • Growth Disorders / blood
  • Growth Disorders / genetics*
  • Humans
  • Male
  • Thyrotropin / blood
  • Thyrotropin / deficiency*
  • Thyrotropin-Releasing Hormone / blood
  • Thyroxine / blood
  • Triiodothyronine / blood


  • Triiodothyronine
  • Thyrotropin-Releasing Hormone
  • Thyrotropin
  • Thyroxine