Characterization of the human factor VIII gene

Nature. 1984 Nov 22-28;312(5992):326-30. doi: 10.1038/312326a0.


The complete 186,000 base-pair (bp) human factor VIII gene has been isolated and consists of 26 exons ranging in size from 69 to 3,106 bp and introns as large as 32.4 kilobases (kb). Nine kb of mRNA and protein-coding DNA has been sequenced and the mRNA termini have been mapped. The relationship between internal duplications in factor VIII and evolution of the gene is discussed.

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • Factor VIII / genetics*
  • Genes
  • Humans
  • Liver / physiology
  • Protein Conformation
  • RNA, Messenger / genetics


  • RNA, Messenger
  • Factor VIII

Associated data

  • GENBANK/X01165
  • GENBANK/X01166