Structure of human factor VIII

Nature. 1984 Nov 22-28;312(5992):337-42. doi: 10.1038/312337a0.


The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Ceruloplasmin
  • Factor VIII*
  • Humans
  • Peptide Fragments / analysis
  • Protein Conformation
  • Protein Precursors
  • Thrombin / metabolism


  • Peptide Fragments
  • Protein Precursors
  • Factor VIII
  • Ceruloplasmin
  • Thrombin