An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function

Vox Sang. 1984;47(5):348-53. doi: 10.1111/j.1423-0410.1984.tb04138.x.


A patient with phenotype R2r and anti-C has a hemolytic transfusion reaction (HTR) with hemoglobinemia and hemoglobinuria which occurred within 2 h of receiving an R1r transfusion. Transient impaired renal function ensued. A patient with phenotype R2R2 and anti-Ce+e had the same experience on day 4 after receiving three R1r and one rr units. 2 other patients, 1 R2r with anti-C who received one R1r unit and the other R2R2 with anti-Ce+e who received two R1r units, showed no clinical evidence of HTR. Both anti-C antibodies were entirely IgG while both anti-Ce+e antibodies initially were predominantly IgM. IgG subclassing was unsuccessful and red blood cell-mononuclear phagocyte assays were normal. These cases occurred from 1979 to 1981.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Blood Group Incompatibility / etiology*
  • Blood Group Incompatibility / immunology
  • Female
  • Hemoglobinuria / etiology
  • Hemolysis
  • Humans
  • Immunoglobulin G / immunology
  • Immunoglobulin M / immunology
  • Isoantibodies / immunology
  • Kidney Diseases / etiology
  • Male
  • Middle Aged
  • Rh-Hr Blood-Group System / immunology*
  • Time Factors
  • Transfusion Reaction*


  • Immunoglobulin G
  • Immunoglobulin M
  • Isoantibodies
  • Rh-Hr Blood-Group System