Chronic hypercapnia stimulates proximal bicarbonate reabsorption in the rat

J Clin Invest. 1984 Dec;74(6):1942-7. doi: 10.1172/JCI111614.

Abstract

The hyperbicarbonatemia of chronic respiratory acidosis might be maintained by a reduction in filtration rate or an enhancement of tubular bicarbonate reabsorption. To investigate this question, 12 Munich-Wistar rats were exposed to a 10% CO2 atmosphere for 6-8 d. Chronic respiratory acidosis developed, with arterial pH 7.30 +/- 0.01, partial pressure of CO2 (pCO2) 80 +/- 2 mmHg, and total CO2 concentration 45 +/- 1 mM. Single nephron glomerular filtration rate was normal (42 +/- 1 nl/min). Chronic hypercapnia caused absolute proximal reabsorption to be significantly stimulated (1,449 +/- 26 pmol/min) as compared with reabsorption previously observed in normal animals (1,075 +/- 74 pmol/min) or in animals subjected to acute hypercapnia (1,200 +/- 59 pmol/min). This is the first demonstration that proximal bicarbonate reabsorption can be stimulated above normal euvolemic values. When eight animals were subsequently allowed to return toward a normocapnic state (arterial pCO2 46 +/- 1 mmHg) over the course of 1-1.5 h, bicarbonate reabsorption was still significantly higher (1,211 +/- 34 pmol/min) than in similarly alkalotic, normocapnic control groups (994 +/- 45 pmol/min). In conclusion, chronic, but not acute, hypercapnia stimulates absolute proximal bicarbonate reabsorption to exceed the level found in normal euvolemic rats.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Absorption
  • Animals
  • Bicarbonates / metabolism*
  • Carbon Dioxide / metabolism
  • Chlorides / metabolism
  • Chronic Disease
  • Glomerular Filtration Rate
  • Hypercapnia / metabolism*
  • Kidney Tubules, Proximal / metabolism*
  • Rats
  • Rats, Inbred Strains

Substances

  • Bicarbonates
  • Chlorides
  • Carbon Dioxide