beta-Phenylethylamine and reinforcement

Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):615-20. doi: 10.1016/0278-5846(84)90023-x.


beta-Phenylethylamine is an endogenous brain amine which has been characterised as an endogenous amphetamine. The rewarding properties of the structurally similar drug amphetamine in humans and other species indicate a possible role for endogenous beta-phenylethylamine in neural processes underlying reward or reinforcement. Evidence for reinforcing properties of beta-phenylethylamine in the drug self-administration and place preference paradigms is briefly reviewed. The possibility that endogenous beta-phenylethylamine may be involved in reinforcement processes is also considered in relation to studies of intracranial self-stimulation. The contrasting aversive stimulus properties of beta-phenylethylamine and of amphetamine are described.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Chemistry
  • Dextroamphetamine / pharmacology
  • Hypothalamus / physiology
  • Phenethylamines / analysis
  • Phenethylamines / pharmacology*
  • Phenethylamines / physiology
  • Rats
  • Reinforcement, Psychology*
  • Selegiline / pharmacology
  • Self Stimulation / drug effects*
  • Self Stimulation / physiology


  • Phenethylamines
  • Selegiline
  • phenethylamine
  • Dextroamphetamine