Sequence of the lactose permease gene

Nature. 1980 Feb 7;283(5747):541-5. doi: 10.1038/283541a0.


The nucleotide sequence of the lacY gene coding for lactose permease (M protein) in Escherichia coli has been determined. The sequence includes the intergenic regions between the lacZ (beta-galactosidase) and lacY genes as well as the region between the lacY and lacA (transacetylase) genes. Lactose permease is predicted to consist of 417 residues (71% nonpolar), resulting in a protein with a molecular weight of 46,504. The reading frame was confirmed by the sequence of a nonsense mutation changing codon 33 from UGG to UAG.

MeSH terms

  • Amino Acid Sequence
  • Bacteriophage lambda / genetics
  • Base Sequence
  • Binding Sites
  • DNA, Bacterial / genetics
  • DNA, Recombinant
  • Escherichia coli / genetics*
  • Genes*
  • Lac Operon*
  • Membrane Transport Proteins / genetics*
  • Ribosomes / metabolism


  • DNA, Bacterial
  • DNA, Recombinant
  • Membrane Transport Proteins

Associated data

  • GENBANK/J01636
  • GENBANK/J01637
  • GENBANK/K01483
  • GENBANK/K01793