Lymphocyte-mediated cytotoxicity and humoral antibodies in human pregnancy

Int Arch Allergy Appl Immunol. 1980;61(4):467-71. doi: 10.1159/000232475.


Lymphocyte-mediated cytotoxicity, antibody-dependent cell cytotoxicity and complement-dependent antibody assays were used to study maternal immune response to fetal antigens present on cord lymphocytes at delivery. Among 24 cell-mediated lympholysis tests, 4 were found slightly positive and accompanied by a complement-dependent antibody and/or an antibody-dependent cell cytotoxicity response. The humoral immune response was found more often positive than the cellular response.

MeSH terms

  • Antibodies*
  • Antibody-Dependent Cell Cytotoxicity
  • Cytotoxicity, Immunologic*
  • Female
  • Fetal Blood / immunology
  • HLA Antigens
  • Humans
  • Immunity, Cellular*
  • Infant, Newborn
  • Leukocyte Migration-Inhibitory Factors
  • Lymphocyte Culture Test, Mixed
  • Lymphocytes / immunology*
  • Placenta / immunology
  • Pregnancy


  • Antibodies
  • HLA Antigens
  • Leukocyte Migration-Inhibitory Factors