Immunity and drug resistance in a mouse glioma

J Surg Oncol. 1980;14(2):125-32. doi: 10.1002/jso.2930140205.

Abstract

The failure of chemotherapy often results in the outgrowth of drug-resistant tumor cells, and, since chemotherapy is often combined with immunotherapy, the question arises as to whether immunity directed against the original tumor offers any protection against the drug-resistant tumor cells. To approach this problem, the immunological relationships between a mouse glioma (GL26) and two FUdR-resistant transplantable tumor sublines were studied. Immunity was induced in C57BL/6 mice with neuraminidase-altered GL26 tumor cells. Immunized mice challenged with viable GL26 tumor cells were completely protected, and no tumors grew. Immune mice, when rechallenged with cells from the two FUdR-resistant tumors, gave greater protection against one of the tumors than the other, but not as much as against the original tumor. The results indicate the drug-resistant tumor cells have some immunological properties similar to the original tumor line and that further studies such as these might be of value to the staging of chemoimmunotherapy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Drug Resistance*
  • Floxuridine
  • Glioma / immunology*
  • Immunity, Cellular*
  • Mice
  • Neoplasm Transplantation
  • Neoplasms, Experimental / immunology*
  • Neuraminidase

Substances

  • Floxuridine
  • Neuraminidase