Effect of experimentally induced diabetes on swine vascular prostacyclin (PGI2) synthesis

Artery. 1980;8(1):30-6.

Abstract

Repeated administration of streptozotocin to Göttingen miniature swine led to the development of a mild form of diabetes. The amount of PGI2 generated by the vessels (abdominal aorta, thoracic aorta, pulmonary artery), as estimated by reference to inhibition of ADP-induced platelet aggregation, was lower in the treated animals than in the controls. The decrease in the synthesis of PGI2 may contribute to the prethrombotic state in diabetes mellitus.

MeSH terms

  • Animals
  • Aorta, Abdominal
  • Aorta, Thoracic
  • Blood Glucose
  • Diabetes Mellitus, Experimental / blood*
  • Epoprostenol / biosynthesis*
  • Insulin / immunology
  • Pancreas / analysis
  • Prostaglandins / biosynthesis*
  • Pulmonary Artery
  • Streptozocin
  • Swine

Substances

  • Blood Glucose
  • Insulin
  • Prostaglandins
  • Streptozocin
  • Epoprostenol