Musculoskeletal manifestations of Paget's disease of bone

Arthritis Rheum. 1980 Oct;23(10):1121-7. doi: 10.1002/art.1780231008.

Abstract

A review of 290 patients with Paget's disease of bone revealed 83% had one or more rheumatic syndromes. The most common finding was back pain (37%), most often related to an independent osteoarthritic process or Paget's disease precipitating or complicating spinal osteoarthritis. Paget's disease as a sole source of back pain was distinctly uncommon (2%). Osteoarthritis related to Paget's disease was present in the hip (30%) and knee (11%). Paget's disease in spondylitis was present in 4 patients and in ankylosing hyperostosis in 4 patients. The latter group had very active Paget's disease. Rheumatoid arthritis (1%), hyperuricemia (20%), and gout (4%) did not appear increased in this group.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alkaline Phosphatase / blood
  • Arthritis, Rheumatoid / complications
  • Back Pain / complications
  • Female
  • Gout / complications
  • Hip Joint
  • Humans
  • Knee Joint
  • Male
  • Middle Aged
  • Osteitis Deformans / complications*
  • Osteoarthritis / complications*
  • Skull / physiopathology
  • Spinal Diseases / complications
  • Spondylitis / complications
  • Uric Acid / blood

Substances

  • Uric Acid
  • Alkaline Phosphatase