A re-examination of the clinical effects of imipramine and amitriptyline in depressive illness

J Affect Disord. 1980 Jun;2(2):89-94. doi: 10.1016/0165-0327(80)90008-7.


A double-blind trial of amitriptyline and imipramine was conducted in patients suffering from depressive illness. The results failed to confirm the prevalent belief that amitriptyline has a greater sedative effect and superior anxiolytic properties than imipramine. The therapeutic effect of these drugs was not shown to be related to their sedative properties and with regard to anxiety the reverse appeared to be true.

MeSH terms

  • Amitriptyline / therapeutic use*
  • Anxiety Disorders / drug therapy
  • Delayed-Action Preparations
  • Depressive Disorder / drug therapy*
  • Double-Blind Method
  • Female
  • Humans
  • Imipramine / therapeutic use*
  • Male
  • Middle Aged


  • Delayed-Action Preparations
  • Amitriptyline
  • Imipramine