Comparative studies on the immunosuppressive effect among 5'-deoxy-5-fluorouridine, ftorafur, and 5-fluorouracil

Gan. 1980 Apr;71(2):190-6.


The immunosuppressive effect of 5'-deoxy-5-fluorouridine (5'-DFUR, Ro 21-9738) was examined for both humoral and cell-mediated immunity in mice in comparison with that of 5-fluorouracil and Ftorafur (FT-207). By both oral and intraperitoneal administration, 5'-DFUR was found to be much less suppressive than 5-fluorouracil and FT-207 in all immune responses tested; hemolysin plaque-forming cells, serum hemolysin titer, delayed-type hypersensitivity and allogeneic tumor rejection. Furthermore, 5'-DFUR did not induce any reduction in either the spleen weight, thymus weight, total spleen cell number, or peripheral leucocyte number.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antibody Formation / drug effects
  • Erythrocytes / immunology
  • Female
  • Floxuridine / pharmacology*
  • Fluorouracil / analogs & derivatives*
  • Fluorouracil / pharmacology*
  • Graft Rejection / drug effects
  • Hypersensitivity, Delayed / immunology
  • Immunity, Cellular / drug effects
  • Immunosuppressive Agents*
  • Male
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Neoplasm Transplantation
  • Tegafur / pharmacology*


  • Immunosuppressive Agents
  • Floxuridine
  • Tegafur
  • Fluorouracil
  • doxifluridine