Dopamine receptor binding is increased in diabetic rats

Science. 1981 Nov 27;214(4524):1031-3. doi: 10.1126/science.6458088.

Abstract

The binding of [3H]spiperone, a dopamine receptor ligand, to striatal membranes was increased 30 to 35 percent in rats made diabetic with alloxan or streptozotocin. Binding of [3H]spiperone was normal in rats made diabetic with alloxan but treated with insulin. Thus the number of dopamine receptors and central dopaminergic transmission may be altered in diabetes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alloxan / pharmacology
  • Animals
  • Blood Glucose / metabolism
  • Cell Membrane / metabolism
  • Corpus Striatum / metabolism*
  • Diabetes Mellitus, Experimental / drug therapy
  • Diabetes Mellitus, Experimental / metabolism*
  • Insulin / therapeutic use
  • Kinetics
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / metabolism*
  • Spiperone / metabolism
  • Streptozocin / pharmacology

Substances

  • Blood Glucose
  • Insulin
  • Receptors, Dopamine
  • Spiperone
  • Streptozocin
  • Alloxan