True Vleminckx's solution incorporated in a natural clay-mask vehicle apparently retains its therapeutic qualities while relinquishing all unaesthetic properties. A double-blind, randomized clinical trial comparing the Vleminckx mask to its vehicle was conducted. While the mask vehicle may not be considered a placebo, only the active drug produced a statistically significant reduction in comedone count at the conclusion of the study. The Vleminckx mask achieved a substantially greater reduction in papule count than the vehicle (p less than 0.05). Male and female patients responded positively to the concept of every-other-evening applications of only 20 minutes, as well as to the mask's rapidly astringent and cooling skin effects.