Effects of a new type of 5-HT receptor agonist on male rat sexual behavior

Pharmacol Biochem Behav. 1981 Nov;15(5):785-92. doi: 10.1016/0091-3057(81)90023-x.


8-Methoxy-2-(di-n-propylamino) tetralin (8-OMe-DPAT) and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) are two new drugs exerting selective actions on brain 5-HT neurotransmission. In the present experiments we have investigated the effects of these two drugs on male rat sexual behavior. It was found that both drugs reduce the number of intromissions preceding ejaculation and shorten the ejaculation latency. These effects are extremely pronounced and several animals ejaculate at the first intromission. In addition 8-OH-DPAT produced a slight reduction of the post-ejaculatory interval. There were no significant effects on latency to initiate copulation or in the number of mounts preceding ejaculation. Finally, sexual behavior was partly or completely restored in castrated male rats after injection with 8-OMe-DPAT or 8-OH-DPAT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Animals
  • Castration
  • DOM 2,5-Dimethoxy-4-Methylamphetamine / pharmacology
  • Ejaculation / drug effects
  • Lysergic Acid Diethylamide / pharmacology
  • Male
  • Quipazine / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Serotonin / drug effects*
  • Sexual Behavior, Animal / drug effects*
  • Tetrahydronaphthalenes / pharmacology


  • Receptors, Serotonin
  • Tetrahydronaphthalenes
  • DOM 2,5-Dimethoxy-4-Methylamphetamine
  • 8-methoxy-2-(di-n-propylamino)tetralin
  • Quipazine
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Lysergic Acid Diethylamide