From grasshopper to Drosophila: a common plan for neuronal development

Nature. 1984 Jul 19-25;310(5974):203-7. doi: 10.1038/310203a0.


Little is known about the mechanisms that generate neuronal specificity during development. Whereas the grasshopper embryo has been an ideal system for a cellular analysis of neuronal development, the Drosophila embryo has obvious attributes for a molecular genetic analysis. Here we show that the early Drosophila embryo is a miniature replica of the grasshopper embryo in terms of its identified neurones, their growth cones and their selective fasciculation choices, thus opening the way for a combined cellular and molecular genetic analysis of cell recognition during neuronal development in Drosophila.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Astacoidea / embryology
  • Axons / ultrastructure
  • Cell Differentiation
  • Central Nervous System / embryology
  • Diptera / embryology
  • Drosophila / embryology*
  • Grasshoppers / embryology*
  • Microscopy, Electron
  • Moths / embryology
  • Neurons / cytology
  • Neurons / physiology*
  • Periplaneta / embryology
  • Rhodnius / embryology
  • Time Factors