Nucleotide sequence comparison of normal and translocated murine c-myc genes

Nature. 1984 Aug 2-8;310(5976):423-5. doi: 10.1038/310423a0.

Abstract

Plasmacytoid tumours in mice and Burkitt's lymphomas in humans display characteristic chromosomal translocations involving the c-myc proto-oncogene. Models to explain quantitative changes in c-myc expression have been proposed based on the loss of normal promoters as a result of translocation. However, alternative explanations, such as somatic mutation are needed to explain altered c-myc expression in the absence of gene breakage. We present here the nucleotide sequence of the normal murine c-myc gene. Comparison of this sequence with that of a translocated c-myc gene from a murine plasmacytoma reveals complete identity of coding sequence. One nucleotide difference was found in the non-coding first exon. This shows that qualitative changes of the c-myc gene product are not required for oncogenesis in murine plasmacytomas. In contrast, mutations are found in coding and non-coding regions of translocated c-myc genes from Burkitt's lymphomas, suggesting that the mechanisms by which c-myc is activated in plasmacytomas and Burkitt's lymphomas are different.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Gene Expression Regulation
  • Genes
  • Mice
  • Mutation
  • Oncogenes*
  • Plasmacytoma / genetics*
  • Spleen / physiology
  • Translocation, Genetic*

Associated data

  • GENBANK/J00373
  • GENBANK/J00374
  • GENBANK/L00038
  • GENBANK/L00039