Fetal growth delay and maternal hemoglobin A1c in early diabetic pregnancy

Obstet Gynecol. 1984 Sep;64(3):351-2.


Forty insulin-dependent diabetic women in the first trimester of pregnancy were studied. Fetal crown-rump length was measured by ultrasound and related to maternal hemoglobin A1c. Thirty mothers with normal size fetuses had an average hemoglobin A1c level of 7.8%. Ten mothers had fetuses that were smaller than normal (equivalent to eight to 14 days less growth) and also had higher hemoglobin A1c, 8.9% (P less than .05), indicating a more poorly controlled diabetes. Careful metabolic compensation in very early diabetic pregnancy should therefore be attempted to prevent induction of early fetal growth delay.

MeSH terms

  • Birth Weight
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / complications*
  • Female
  • Fetal Growth Retardation / etiology*
  • Gestational Age
  • Glycated Hemoglobin A / analysis*
  • Humans
  • Infant, Newborn
  • Pregnancy
  • Pregnancy in Diabetics / blood
  • Pregnancy in Diabetics / complications*


  • Glycated Hemoglobin A