Multiple synostosis syndrome: study of a large Brazilian kindred

Am J Med Genet. 1984 Jun;18(2):237-47. doi: 10.1002/ajmg.1320180208.

Abstract

We report a large Brazilian kindred with 28 cases of the autosomal dominant multiple synostosis syndrome. The main anomalies were symphalangism and carpal and tarsal synostoses. Other common findings included synostosis involving other bones, absence of phalanges and nails, short metacarpals, pes planovalgus with prominent lateral border, hypoplastic alae of nose, short upper lip, and dermatoglyphic abnormalities. This may be a variant of the WL syndrome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormalities, Multiple / diagnosis
  • Abnormalities, Multiple / genetics*
  • Adolescent
  • Adult
  • Aged
  • Brazil
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pedigree
  • Syndrome
  • Synostosis / diagnosis
  • Synostosis / genetics*