Ischemic cerebral changes in the chronic chagasic cardiopathy

Arq Neuropsiquiatr. 1984 Jun;42(2):105-15. doi: 10.1590/s0004-282x1984000200002.


The pathological systematized study of the brain of 31 cases of the chronic cardiac form of Chagas' disease was undertaken. Elective parenchymatous necrosis was found in 64.5% of cases, mainly in cerebellar Purkinje cells, and in thalamic nuclei. Also found were multiple foci of old micronecrosis (51.6%) mostly in the cerebral cortex, old cerebral infarcts (22.6%), cortical laminar necrosis (16.1%) and cerebral cortical atrophy (3.2%). These findings are not specific and can be explained by thromboembolic phenomena and hypoxemia following from congestive heart failure and disturbances of the cardiac rhythm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Brain / pathology*
  • Brain Ischemia / etiology
  • Brain Ischemia / pathology*
  • Cerebral Infarction / etiology
  • Cerebral Infarction / pathology*
  • Chagas Cardiomyopathy / complications*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Necrosis