Major hemorrhage following administration of intrapleural streptokinase

Chest. 1984 Sep;86(3):486-7. doi: 10.1378/chest.86.3.486.


Severe spontaneous bleeding has not been reported to complicate therapy with intrapleural streptokinase (SK). Recent data have demonstrated intrapleural SK to be devoid of systemic fibrinolytic effect. This report presents a patient who suffered major hemorrhage following the administration of 500,000 units of SK intrapleurally.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Hemorrhage / chemically induced*
  • Humans
  • Lung Diseases / chemically induced*
  • Lung Diseases / drug therapy
  • Lung Diseases / physiopathology
  • Male
  • Pleural Effusion / therapy
  • Streptokinase / adverse effects*


  • Streptokinase