Mechanism of Coumarin Action: Significance of Vitamin K Epoxide Reductase Inhibition

Biochemistry. 1978 Apr 18;17(8):1371-7. doi: 10.1021/bi00601a003.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Drug Resistance
  • Glutamates
  • Ligases / metabolism
  • Male
  • Microsomes, Liver / enzymology*
  • Mixed Function Oxygenases / antagonists & inhibitors*
  • Models, Biological
  • Oxidation-Reduction
  • Prothrombin
  • Rats
  • Vitamin K
  • Vitamin K Deficiency / enzymology*
  • Warfarin / pharmacology*

Substances

  • Glutamates
  • Vitamin K
  • Warfarin
  • Prothrombin
  • Mixed Function Oxygenases
  • Ligases