Pharmacokinetics of iohexol, a new nonionic radiocontrast agent, in humans

J Pharm Sci. 1984 Jul;73(7):993-5. doi: 10.1002/jps.2600730735.

Abstract

Sixteen healthy men received iohexol intravenously at a concentration of 346 mg of iodine/mL. Doses of 500, 750, 1000, and 1500 mg of iodine/kg of body weight were administered to four volunteers each. Neither clearance nor percent of dose excreted in the urine showed any significant correlation with size of the dose. The overall mean (+/- SD) renal and total body clearances were 120 +/- 18.6 and 131 +/- 18.6 mL/min, respectively. The overall mean apparent volume of distribution was 165 (+/- 30.7) mL/kg. Urine contained 92.3 +/- 4.4% of the dose. Most of the drug (89.9%) was excreted within the first 12 h. An open three-compartment body model gave the best fit to the experimental data. The mean apparent first-order terminal elimination (gamma-phase) half-life was 12.6 h.

MeSH terms

  • Adolescent
  • Adult
  • Contrast Media / administration & dosage
  • Humans
  • Injections, Intravenous
  • Iodobenzoates / metabolism*
  • Iohexol
  • Kinetics
  • Male
  • Middle Aged
  • Triiodobenzoic Acids / administration & dosage
  • Triiodobenzoic Acids / metabolism*

Substances

  • Contrast Media
  • Iodobenzoates
  • Triiodobenzoic Acids
  • Iohexol