Transient heterosynaptic depression in the hippocampal slice

Brain Res Bull. Mar-Apr 1978;3(2):181-4. doi: 10.1016/0361-9230(78)90045-x.


Two independent, excitatory, monosynaptic afferent fiber systems projecting onto basal and apical dendritic layers of the CA1 sub-field of the hippocampus were tested for interactive effects. Long-term potentiation of either of the pathways was accompanied by a transient depression in the other pathway. Similar transient depression could be elicited by antidromic stimulation of the CA1 cells. No long-term heterosynaptic effects were observed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Afferent Pathways / physiology
  • Animals
  • Electric Stimulation / methods
  • Evoked Potentials
  • Hippocampus / physiology*
  • Male
  • Membrane Potentials
  • Neural Inhibition*
  • Neurons / physiology
  • Rats
  • Synapses / physiology*