Induction of mammary tumors with metronidazole in female Sprague-Dawley rats

Tumori. 1984 Aug 31;70(4):307-11.

Abstract

Sprague-Dawley rats were administered low doses of metronidazole similar to those used in humans, and then subjected to a long-term follow-up. Metronidazole caused a significant rise in mammary tumors in the female rats (p less than 0.001) after a mean latency period of 100.5 weeks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / chemically induced
  • Adenofibroma / chemically induced
  • Animals
  • Female
  • Mammary Neoplasms, Experimental / chemically induced*
  • Mammary Neoplasms, Experimental / pathology
  • Metronidazole*
  • Rats
  • Time Factors

Substances

  • Metronidazole