Abstract
A boy with chronic granulomatous disease received a bone-marrow graft from a fully compatible unrelated donor, in association with a modified immunosuppressant regimen. He showed considerable clinical improvement with definite evidence of engraftment, and he has enjoyed a normal life for over 3 years.
MeSH terms
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ABO Blood-Group System
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Bone Marrow Cells*
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Bone Marrow Transplantation*
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Child
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Cyclophosphamide / therapeutic use
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Female
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Graft Survival
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Granulomatous Disease, Chronic / genetics
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Granulomatous Disease, Chronic / immunology
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Granulomatous Disease, Chronic / therapy*
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HLA Antigens / analysis
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Histocompatibility Testing
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Humans
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Lymphocyte Culture Test, Mixed
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Male
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Neutrophils
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Nitroblue Tetrazolium
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Phagocyte Bactericidal Dysfunction / therapy*
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Preoperative Care
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Rh-Hr Blood-Group System
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Sex Chromosome Aberrations
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Tissue Donors
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Transplantation, Homologous
Substances
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ABO Blood-Group System
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HLA Antigens
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Rh-Hr Blood-Group System
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Nitroblue Tetrazolium
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Cyclophosphamide