High affinity binding of ochratoxin A to plasma constituents

Biochem Int. 1984 Jul;9(1):33-8.


The binding properties of ochratoxin A to human and porcine plasma constituents were studied in vitro. Ochratoxin A was shown to bind to other plasma constituents with a considerably higher affinity than the earlier known nonspecific binding to plasma albumins. The association constant for the high affinity macromolecule (s) in human plasma was found to be 2.3 X 10(10) M-1 and for porcine plasma 0.59 X 10(10) M-1. The macromolecule (s) to which ochratoxin A binds more specifically than to albumins have not been identified, but their molecular weights were estimated by gel filtration to be 20 000.

MeSH terms

  • Animals
  • Blood Proteins / metabolism*
  • Humans
  • Kinetics
  • Molecular Weight
  • Ochratoxins / blood*
  • Protein Binding
  • Serum Albumin / metabolism*
  • Swine


  • Blood Proteins
  • Ochratoxins
  • Serum Albumin
  • ochratoxin A