Type II collagen-induced arthritis in mice. II. Passive transfer and suppression by intravenous injection of anti-type II collagen antibody or free native type II collagen

Arthritis Rheum. 1984 Sep;27(9):1010-7. doi: 10.1002/art.1780270907.


The passive transfer of high levels of anti-type II collagen antibody from mice with type II collagen-induced arthritis may transfer arthritis to syngeneic recipient animals. However, the transfer of either arthritogenic or sub-arthritogenic doses of polyclonal anti-type II collagen antibody, or non-arthritogenic monoclonal anti-type II collagen antibody may protect mice against the subsequent induction of arthritis by type II collagen. A protective effect was also observed in mice given free native type II collagen intravenously before the administration of collagen in an arthritogenic protocol.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Arthritis / immunology*
  • Arthritis, Experimental / immunology*
  • Autoantibodies / immunology*
  • Chickens
  • Collagen / immunology*
  • Cross Reactions
  • Immunization, Passive*
  • Immunosuppression Therapy*
  • Mice
  • Mice, Inbred DBA
  • Mice, Inbred Strains


  • Antibodies, Monoclonal
  • Autoantibodies
  • Collagen