Urinary excretion of macromolecular acidic glycosaminoglycans in Werner's syndrome

Clin Chim Acta. 1978 Apr 17;85(2):101-6. doi: 10.1016/0009-8981(78)90227-9.

Abstract

The urinary acidic glycosaminoglycans (AGAG) of Werner's syndrome were isolated, purified and characterized by gel-chromatography, cellulose acetate electrophoresis, chemical analysis, streptomyces hyaluronidase susceptibility and viscometry. The AGAG appeared at the first peaks of the 0.6 M and 0.8 M fractions obtained through Sephadex G-100 were mainly a a hyaluronic acid (HA). HA was composed of 16% of the urinary AGAG. The AGAG at the first peak had the maximum molecular weight of 360 000 in the 0.8 M fraction followed by lesser molecular weights in the other fractions.

MeSH terms

  • Adult
  • Glycosaminoglycans / urine*
  • Humans
  • Middle Aged
  • Molecular Weight
  • Viscosity
  • Werner Syndrome / urine*

Substances

  • Glycosaminoglycans