Soybean-protein diet in the treatment of type-II hyperlipoproteinaemia

Lancet. 1977 Feb 5;1(8006):275-7. doi: 10.1016/s0140-6736(77)91823-2.

Abstract

A soybean textured protein induced a 14% decrease of plasma-cholesterol levels after two weeks and 21% after three when substituted for animal proteins in a group of 20 patients with type-II hyperlipoproteinaemia. Comparison of soybean diet with a standard low-lipid diet in the same patients, according to a cross-over protocol, indicated that this hypocholesterolaemic effect was not due to differences in the lipid composition of the two diets. The hypothesis that a soy protein has a hypocholesterolaemic action per se is supported by the results of a subsequent experiment in 8 type-II patients in whom the addition of cholesterol (500 mg/day) to soy protein did not modify the hypocholesterolaemic response.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Cholesterol / blood
  • Cholesterol, Dietary / administration & dosage
  • Clinical Trials as Topic
  • Dietary Fats / administration & dosage
  • Dietary Proteins / administration & dosage
  • Dietary Proteins / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperlipidemias / blood
  • Hyperlipidemias / diet therapy*
  • Lipoproteins, LDL / blood
  • Male
  • Middle Aged
  • Plant Proteins, Dietary / administration & dosage
  • Plant Proteins, Dietary / therapeutic use*
  • Soybeans*
  • Triglycerides / blood

Substances

  • Cholesterol, Dietary
  • Dietary Fats
  • Dietary Proteins
  • Lipoproteins, LDL
  • Plant Proteins, Dietary
  • Triglycerides
  • Cholesterol