Low-sulfur hair syndrome associated with UVB photosensitivity and testicular failure

J Am Acad Dermatol. 1984 Aug;11(2 Pt 2):340-6. doi: 10.1016/s0190-9622(84)70169-1.


A 16-year-old male patient had a syndrome that included growth retardation, mental retardation, hair shaft abnormalities, neurosensory hearing loss, contractures of the fifth fingers, ultraviolet B (UVB) photosensitivity, small testicular size, and elevated levels of follicle-stimulating hormone. Reduced hair sulfur content and a characteristic pattern of light and dark birefringent bands, seen when hairs were viewed with polarization microscopy, were typical of the low-sulfur hair syndrome. UVB photosensitivity and testicular failure have not previously been identified as components of this syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Dwarfism / genetics
  • Hair / metabolism
  • Hair Diseases / genetics*
  • Hearing Loss, Sensorineural / genetics
  • Humans
  • Hypogonadism / genetics*
  • Intellectual Disability / genetics
  • Male
  • Photosensitivity Disorders / genetics*
  • Sulfur / metabolism*
  • Syndrome


  • Sulfur