Cryotherapy for treatment of genital condylomata acuminata was safely and successfully employed on 34 pregnant women in the second (4 cases) and third (30 cases) trimesters of pregnancy. No fetal, maternal or neonatal complications occurred during or following cryosurgery. No recurrences were observed before or six weeks following delivery. Cryotherapy eliminated the need for elective cesarean section in many patients with genital condylomata. Cryotherapy can be safely employed on pregnant women on an outpatient basis irrespective of the gestational period.