The ability of certain anorexic drugs to suppress food consumption depends on the nutrient composition of the test diet

Life Sci. 1984 Sep 17;35(12):1297-300. doi: 10.1016/0024-3205(84)90101-2.


The effects of five anorexic agents on food consumption were tested in rats offered single, isocaloric, isonitrogenous diets differing in carbohydrate content. Three of the test agents, d-amphetamine, benzphetamine and chlorphentermine, are sympathomimetic and cause CNS stimulation; the others, MK-212 and d-fenfluramine, are thought to facilitate serotonin-mediated neurotransmission. At ED50 doses, the sympathomimetic drugs reduced food consumption whether the test diet was rich (75% dextrin) or poor (25% dextrin) in carbohydrate. In contrast, MK-212 and d-fenfluramine failed to reduce consumption of the 25% dextrin test diet. These observations suggest that anorexic drugs like d-amphetamine and d-fenfluramine do not act via a common "amphetamine receptor," and are compatible with earlier observations, made on rats given diet pairs simultaneously, that enhanced serotoninergic neurotransmission selectively suppresses appetite for carbohydrates.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Appetite Depressants / pharmacology*
  • Benzphetamine / pharmacology
  • Chlorphentermine / pharmacology
  • Dextroamphetamine / pharmacology
  • Dietary Carbohydrates / pharmacology*
  • Eating / drug effects*
  • Fenfluramine / pharmacology
  • Male
  • Pyrazines / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Serotonin / physiology


  • Appetite Depressants
  • Dietary Carbohydrates
  • Pyrazines
  • Benzphetamine
  • Fenfluramine
  • Serotonin
  • 6-chloro-2-(1-piperazinyl)pyrazine
  • Chlorphentermine
  • Dextroamphetamine