Structure of the Nucleosome Core Particle at 7 A Resolution

Nature. 1984 Oct 11-17;311(5986):532-7. doi: 10.1038/311532a0.


The crystal structure of the nucleosome core particle has been solved to 7 A resolution. The right-handed B-DNA superhelix on the outside contains several sharp bends and makes numerous interactions with the histone octamer within. The central turn of superhelix and H3 . H4 tetramer have dyad symmetry, but the H2A . H2B dimers show departures due to interparticle associations.

MeSH terms

  • Animals
  • Cattle
  • DNA, Superhelical*
  • Histones*
  • Kidney / ultrastructure
  • Macromolecular Substances
  • Nucleosomes / ultrastructure*
  • X-Ray Diffraction


  • DNA, Superhelical
  • Histones
  • Macromolecular Substances
  • Nucleosomes