High dose barbiturate therapy in neurosurgery and intensive care

Neurosurgery. 1984 Sep;15(3):427-44. doi: 10.1227/00006123-198409000-00023.

Abstract

To assess the uses of high dose barbiturate therapy in neurosurgery and intensive care, the authors have undertaken a concise survey of relevant experimental investigations and a comprehensive review of published clinical experiences.

MeSH terms

  • Barbiturates / therapeutic use*
  • Brain / drug effects
  • Brain Diseases / surgery*
  • Brain Edema / drug therapy
  • Brain Ischemia / drug therapy
  • Cerebrovascular Circulation / drug effects
  • Critical Care / methods*
  • Dose-Response Relationship, Drug
  • Electroencephalography
  • Energy Metabolism / drug effects
  • Humans
  • Intracranial Pressure / drug effects
  • Lipid Peroxides / metabolism
  • Oxygen Consumption / drug effects
  • Pentobarbital / therapeutic use
  • Phenobarbital / therapeutic use
  • Thiopental / therapeutic use

Substances

  • Barbiturates
  • Lipid Peroxides
  • Pentobarbital
  • Thiopental
  • Phenobarbital