Habituation of exploratory activity in mice: effects of combinations of piracetam and choline on memory processes

Pharmacol Biochem Behav. 1984 Aug;21(2):209-12. doi: 10.1016/0091-3057(84)90216-8.


The effects of various piracetam + choline combinations on an experimental model of memory were investigated. Mice were given two sessions in a simple photo-cell activity cage and the decrease in activity at the second session (habituation) served as an index of retention. Retention was facilitated by post-session administration of 2000 mg/kg piracetam IP and 50 mg/kg piracetam + 50 mg/kg choline IP. Similar injections of choline alone (10 to 200 mg/kg IP), piracetam alone (10 to 1000 mg/kg IP) or other combinations of piracetam and choline were without effect. These results, consistent with those reported elsewhere, suggest that piracetam can interact with choline to facilitate memory processes in mice.

MeSH terms

  • Animals
  • Choline / pharmacology*
  • Drug Interactions
  • Exploratory Behavior / drug effects*
  • Habituation, Psychophysiologic / drug effects*
  • Male
  • Memory / drug effects*
  • Mice
  • Piracetam / pharmacology*
  • Pyrrolidinones / pharmacology*


  • Pyrrolidinones
  • Choline
  • Piracetam