Effect of zinc supplementation on copper status in adult man

Am J Clin Nutr. 1984 Oct;40(4):743-6. doi: 10.1093/ajcn/40.4.743.


The effects of zinc supplementation on the copper status of healthy adult men, as assessed by the activities of the copper-metalloenzymes, plasma ferroxidase (ceruloplasmin), and erythrocyte Cu,Zn-superoxide dismutase, were determined. The subjects were given either two daily doses of 25 mg zinc or placebo for 6 wk. No significant differences in the plasma copper levels or the ferroxidase activities between the supplemented and control groups could be detected at 2, 4, or 6 wk. Plasma zinc increased and erythrocyte Cu,Zn-superoxide dismutase decreased in the supplemented group, the difference between the groups becoming significant at 6 wk (p less than 0.05). This suggested that the zinc supplements decreased the copper status of the experimental group.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Ceruloplasmin / metabolism
  • Copper / blood*
  • Copper / deficiency
  • Diet
  • Erythrocytes / enzymology*
  • Humans
  • Liver / enzymology
  • Male
  • Superoxide Dismutase / blood
  • Zinc / adverse effects*
  • Zinc / blood


  • Copper
  • Superoxide Dismutase
  • Ceruloplasmin
  • Zinc