The binding and subsequent inhibition of tubulin polymerization in Ascaris suum (in vitro) by benzimidazole anthelmintics

Biochem Pharmacol. 1984 Oct 1;33(19):3037-40. doi: 10.1016/0006-2952(84)90605-1.

Abstract

Benzimidazole anthelmintics may act by interfering with the microtubule system in Ascaris suum. Binding of benzimidazole anthelmintics, and their inactive metabolites, to A. suum tubulin was demonstrated by the inhibition of intestinal extracts of the nematode to bind [3H]colchicine. In addition, these compounds inhibited the polymerization of tubulin into microtubules in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / pharmacology*
  • Ascaris / metabolism*
  • Benzimidazoles / metabolism
  • Benzimidazoles / pharmacology*
  • Colchicine / metabolism
  • In Vitro Techniques
  • Polymers / metabolism
  • Sulfhydryl Compounds / pharmacology
  • Tubulin / metabolism*

Substances

  • Anthelmintics
  • Benzimidazoles
  • Polymers
  • Sulfhydryl Compounds
  • Tubulin
  • Colchicine