A Novel Biologically Active Seleno-Organic compound--I. Glutathione Peroxidase-Like Activity in Vitro and Antioxidant Capacity of PZ 51 (Ebselen)

Biochem Pharmacol. 1984 Oct 15;33(20):3235-9. doi: 10.1016/0006-2952(84)90083-2.

Abstract

a synthetic seleno-organic compound, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ 51), exhibits GSH peroxidase-like activity in vitro, in contrast to its sulfur analog, PZ 25. In addition, PZ 51 behaves as an antioxidant shown by a temporary protection of rat liver microsomes against ascorbate/ADP-Fe-induced lipid peroxidation, an effect also elicited by PZ 25 but to a smaller extent. This protection against lipid peroxidation is independent of GSH and of P-450 monooxygenase activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants*
  • Azoles / pharmacology*
  • Glutathione Peroxidase / metabolism*
  • In Vitro Techniques
  • Lipid Peroxides / metabolism
  • Male
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / metabolism
  • Organoselenium Compounds*
  • Rats
  • Rats, Inbred Strains
  • Selenium*

Substances

  • Antioxidants
  • Azoles
  • Lipid Peroxides
  • Organoselenium Compounds
  • ebselen
  • Glutathione Peroxidase
  • Selenium