Erosive azotemic osteoarthropathy

Arthritis Rheum. 1984 Oct;27(10):1086-94. doi: 10.1002/art.1780271002.


Fifty-nine patients with end-stage renal disease undergoing long-term dialysis were studied prospectively for joint disease. Radiographic assessment allowed division of patients into 3 groups: group 1 included 12 patients with renal osteodystrophy and erosions of the metacarpophalangeal, proximal interphalangeal, distal interphalangeal, shoulder, wrist, and knee joints; group 2 had 11 patients with renal osteodystrophy without articular erosions; group 3 included 36 patients without osteodystrophy or erosions. Clinical manifestations were frequent in patients of group 1 and included episodes of arthralgias of the metacarpophalangeal, wrist, proximal interphalangeal, and knee joints. Patients of groups 1 and 2, particularly those of group 1, had a longer mean duration of dialysis and a higher mean serum alkaline phosphatase level compared with group 3 patients. The study indicates that there is a relatively high incidence (20%) of erosive arthropathy in dialysis patients. Renal osteodystrophy, more specifically, secondary hyperparathyroidism, and duration of dialysis are important factors in the development of this articular disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bone Diseases / diagnostic imaging
  • Bone Diseases / etiology*
  • Bone Diseases / pathology
  • Chronic Kidney Disease-Mineral and Bone Disorder / diagnostic imaging
  • Chronic Kidney Disease-Mineral and Bone Disorder / etiology
  • Chronic Kidney Disease-Mineral and Bone Disorder / pathology
  • Female
  • Humans
  • Joint Diseases / diagnostic imaging
  • Joint Diseases / etiology*
  • Joint Diseases / pathology
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Osteoarthritis / diagnostic imaging
  • Osteoarthritis / etiology
  • Osteoarthritis / pathology
  • Prospective Studies
  • Radiography
  • Renal Dialysis / adverse effects
  • Synovial Fluid / cytology
  • Uremia / complications*